The game loads, sets the desktop resolution to 1920x1080, and briefly displays the starmade window at 1280x720. The game loads normally. Then the main menu is displayed, however the mouse cursor is locked to that original 1280x720 rectangle, and all user interface clicks are scaled into that region. So nothing that is displayed can be used by clicking on it where it is on the screen.
I tried changing the resolution, but only just managed to select the "Graphics" panel, and could not click on the toggle fullscreen button.