This has been an issue for a while due to the way I end up playing. I accidentally bash the "+" key on the Number pad which instantly brings up the game options. However this isnt an issue if it didnt cause the game to be unresponsive after using the Escape key twice to dismiss it, and the in game menu that pops up.
Before hitting the Numpad's "+" key Hitting Numpad "+" Escape for the first time Escape the second time. Controls now unresponsive and GUI dissappearsIn order to continue play, one has to hit escape again, then manually click "resume" (Or the X) in order to get GUI and controls back.
This has been in the game a long time, think its about time its reported at least...