Doesn't seem to depend on specific things, just drops everything in the chest. Multi slot or a normal one, it doesn't seem to care.(Bleeding when over capacity is enabled)
How to reproduce:
# enable bleeding when over capacity
# link a chest to a few cargo spaces
# put a few stacks in it (preferably some that are under the volume of the default chest size so they should not get dropped)
# unlink cargo spaces and waitDefault chest capacity is 100 now. If you put items in that in total take 100 volume or less, it's fine on every load/unload.
If you go above it, even though you have enough max volume thanks to linked cargo spaces, it will trigger bleeding immediately when you load the sector.
# drops everythingIt also drops a duplicate stack of its inventory outside...but the stack does disappear inside the chest next time you load it so it still synchs eventually.